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COMPLEMENT FACTOR I
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DeCS
Descriptor
English
:
Complement Factor I
Descriptor
Spanish
:
Factor I de Complemento
Descriptor
Portuguese
:
Fator I do Complemento
Tree Number:
D08.811.277.656.300.760.210
D08.811.277.656.959.350.210
D12.776.124.486.274.920.325.210
Definition
English
:
A
plasma
serine
proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors
COMPLEMENT FACTOR H
and C4-binding protein, respectively. It is a 66-kDa glycoprotein that converts C3b to inactivated C3b (iC3b) followed by the release of two fragments, C3c (150-kDa) and C3dg (41-kDa). It was formerly called KAF, C3bINF, or enzyme 3b inactivator.
Indexing Annotation
English
:
do not confuse with FACTOR I see
FIBRINOGEN
Pharmacological Action:
Complement Inactivating Agents
History Note
English
:
93; was FACTOR I, C 3B INACTIVATOR (NM) 1983-92
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
30774
Unique Identifier:
D017244
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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